Journal of Current Medical Research and Practice

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 5  |  Issue : 1  |  Page : 14--22

Evaluation of bone mineral density and vitamin D in patients with systemic lupus erythematosus and their relation to disease activity


Essam A M. Abda1, Mohamed Esmail2, Mohamed Z Abd Elrhman3, Nadia M Ismail1, Zeinab S Noaman4, Samar H Goma1 
1 Department of Physical Medicine, Rheumatology and Rehabilitation, Assiut University Hospitals, Assiut, Egypt
2 Department of Physical Medicine, Rheumatology and Rehabilitation, Al-Azhar (Assiut Branch) University Hospitals, Assiut, Egypt
3 Department of Clinical Pathology, Assiut University Hospitals, Assiut, Egypt
4 Department of Physical Medicine, Rheumatology and Rehabilitation, Health Insurance, Assiut University, Assiut, Egypt

Correspondence Address:
Samar H Goma
Department of Physical Medicine, Rheumatology and Rehabilitation, Assiut University Hospitals, Assiut 71515
Egypt

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects multiple systems and is associated with an inflammatory status. The aim of our study is to estimate the serum level of vitamin D and bone mineral density (BMD) in SLE patients and their relation to disease activity. Patients and methods: Ninety SLE patients, fulfilling the updated American College of Rheumatology criteria 2012 and 60 age-matched and sex-matched controls were included in this study. The level of serum 25-hydroxyvitamin D (25(OH)D3) and dual-energy radiograph absorptiometry were done for patients and controls. Results: There was significant difference between systemic lupus erythematosus disease activity index (SLEDAI) score and vitamin D (P <0.02). There were significant difference (P <0.01) between SLE and control with BMD of total lumbar (L1–L4) and total hip and highly significant difference (P <0.001) with neck of the femur, Ward's angle of the femur, trochanter of the femur, and the radius. There was significant difference (P<0.05) between SLE and control groups regarding T score of lumbar spine (L1–L4) (P <0.03), neck of the femur (P<0.01), and total hip bone (P <0.02). Our results showed that there was significant difference between SLEDAI score and T score of neck of the femur (P <0.02) and radius bone (P <0.012), while there was no significant difference between SLEDAI score and T score of total hip, lumbar spine (L1–L4), Ward's angle of the femur, and the trochanter of the femur. Conclusion: Vitamin D deficiency and low BMD are common in SLE patients. There was significant difference between SLE patients and control group regarding vitamin D, BMD, and T score at different sites.


How to cite this article:
Abda EA, Esmail M, Abd Elrhman MZ, Ismail NM, Noaman ZS, Goma SH. Evaluation of bone mineral density and vitamin D in patients with systemic lupus erythematosus and their relation to disease activity.J Curr Med Res Pract 2020;5:14-22


How to cite this URL:
Abda EA, Esmail M, Abd Elrhman MZ, Ismail NM, Noaman ZS, Goma SH. Evaluation of bone mineral density and vitamin D in patients with systemic lupus erythematosus and their relation to disease activity. J Curr Med Res Pract [serial online] 2020 [cited 2021 Apr 19 ];5:14-22
Available from: http://www.jcmrp.eg.net/article.asp?issn=2357-0121;year=2020;volume=5;issue=1;spage=14;epage=22;aulast=Abda;type=0