| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 5
| Issue : 1 | Page : 14-22 |
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Evaluation of bone mineral density and vitamin D in patients with systemic lupus erythematosus and their relation to disease activity
Essam A M. Abda1, Mohamed Esmail2, Mohamed Z Abd Elrhman3, Nadia M Ismail1, Zeinab S Noaman4, Samar H Goma1
1 Department of Physical Medicine, Rheumatology and Rehabilitation, Assiut University Hospitals, Assiut, Egypt
2 Department of Physical Medicine, Rheumatology and Rehabilitation, Al-Azhar (Assiut Branch) University Hospitals, Assiut, Egypt
3 Department of Clinical Pathology, Assiut University Hospitals, Assiut, Egypt
4 Department of Physical Medicine, Rheumatology and Rehabilitation, Health Insurance, Assiut University, Assiut, Egypt
Correspondence Address:
Samar H Goma
Department of Physical Medicine, Rheumatology and Rehabilitation, Assiut University Hospitals, Assiut 71515
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/JCMRP.JCMRP_157_19
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Background:
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects multiple systems and is associated with an inflammatory status. The aim of our study is to estimate the serum level of vitamin D and bone mineral density (BMD) in SLE patients and their relation to disease activity.
Patients and methods:
Ninety SLE patients, fulfilling the updated American College of Rheumatology criteria 2012 and 60 age-matched and sex-matched controls were included in this study. The level of serum 25-hydroxyvitamin D (25(OH)D3) and dual-energy radiograph absorptiometry were done for patients and controls.
Results:
There was significant difference between systemic lupus erythematosus disease activity index (SLEDAI) score and vitamin D (P <0.02). There were significant difference (P <0.01) between SLE and control with BMD of total lumbar (L1–L4) and total hip and highly significant difference (P <0.001) with neck of the femur, Ward's angle of the femur, trochanter of the femur, and the radius. There was significant difference (P<0.05) between SLE and control groups regarding T score of lumbar spine (L1–L4) (P <0.03), neck of the femur (P<0.01), and total hip bone (P <0.02). Our results showed that there was significant difference between SLEDAI score and T score of neck of the femur (P <0.02) and radius bone (P <0.012), while there was no significant difference between SLEDAI score and T score of total hip, lumbar spine (L1–L4), Ward's angle of the femur, and the trochanter of the femur.
Conclusion:
Vitamin D deficiency and low BMD are common in SLE patients. There was significant difference between SLE patients and control group regarding vitamin D, BMD, and T score at different sites.
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