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 Table of Contents  
ORIGINAL ARTICLE
Year : 2020  |  Volume : 5  |  Issue : 2  |  Page : 164-167

Percutaneous cystolithotripsy in the management of pediatric bladder stone


Urology, Faculty of Medicine, Assiut University, Asyut, Egypt

Date of Submission26-Aug-2019
Date of Decision29-Aug-2019
Date of Acceptance04-Sep-2019
Date of Web Publication16-May-2020

Correspondence Address:
A A Kamel
Department of Urology, Faculty of Medicine, Assiut University, Asyut
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JCMRP.JCMRP_131_19

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  Abstract 


Background
Bladder stones in children represent up to 15% of all pediatric urolithiasis. Variant methods of managing vesical stones in children are available now with comparable success rates. Percutaneous cystolithotripsy (PCCL) was introduced to our department to be offered for male children on a routine basis.
Aim
To evaluate our experience in managing bladder stones in male children less than 14 years of age via PCCL regarding safety and efficacy.
Patients and methods
A total of 37 children underwent PCCL for their bladder stones in the period between November 2016 and November 2017 in Assiut Urology and Nephrology Hospital. Their median age was 36 (12–144) months and median stone size was 11 (7–26) mm. Initial diagnosis was urethral stones in 26 (70.3%) patients and bladder stones in 11 (29.7%) patients. Patients were followed up for periods ranging from 5 to 33 months (median 18 months).
Results
The median operative time was 14 (5–45) min. Twenty-one (56.8%) patients underwent direct stone extraction without disintegration of their bladder stones. Sixteen (43.2%) patients needed disintegration of their stones, of which 13 (81.25%) had pneumatic disintegration of their stones, whereas three (18.75%) had laser disintegration. Success was achieved in 36 (97.3%) patients. Complications were reported in three (8.1%) cases, and prolonged catheterization was reported in two (5.4%) patients.
Conclusion
PCCL is a safe and effective minimally invasive method for treating bladder stones in children.

Keywords: bladder, children, percutaneous, stones


How to cite this article:
Kamel A A, Shahat A A, Safwat A S, Abdaallah A K. Percutaneous cystolithotripsy in the management of pediatric bladder stone. J Curr Med Res Pract 2020;5:164-7

How to cite this URL:
Kamel A A, Shahat A A, Safwat A S, Abdaallah A K. Percutaneous cystolithotripsy in the management of pediatric bladder stone. J Curr Med Res Pract [serial online] 2020 [cited 2020 Jun 5];5:164-7. Available from: http://www.jcmrp.eg.net/text.asp?2020/5/2/164/284389




  Introduction Top


Bladder stones represented a serious problem to the ancient Egyptians; the oldest stone on record was a bladder calculus found in 1901 by the English Egyptologist Sir Grafton Eliot Smith in a prehistoric Egyptian tomb in the pelvis of a 16-year-old boy's mummy in Egypt[1]. Urinary bladder stones are more common in male children, with a male to female ratio of 10: 1. This is presumably owing to the differences in the anatomy of the male and female urethras[2]. Girls can pass fragments of stones more frequently without retaining nuclei in the bladder[3],[4],[5].

The size and composition of the stone, underlying comorbidity, previous surgery, patient morphology and compliance, operative costs, surgical expertise, and available instrumentation should be considered before definite treatment. Open cystolithotomy has been the traditional modality to treat bladder stones in children. Open surgery has the inherent problems of a long hospital stay, being cosmetically bad from the suprapubic scar, prolonged catheterization, need for analgesics, and the risk of wound infection[6].

The advents of improved endoscopic techniques and related technology have made endoscopic management of bladder stones feasible. Vesical calculi in children can be treated endoscopically with disintegration of the stones using pneumatic lithotripsy or holmium: yttrium–aluminum–garnet laser lithotripsy. Transurethral disintegration for urinary bladder stones is a common method; however, in children, especially in boys, a smaller caliber urethra limits effective transurethral treatment of large bladder stones. Transurethral endoscopic removal of stone fragments is difficult and fraught with iatrogenic urethral stricture. Percutaneous cystolithotripsy (PCCL), however, is now used worldwide. It has less morbidity than open surgery and fewer limitations than the transurethral endoscopic route[7].

On the contrary, PCCL has some disadvantages, such as the presence of an incision, the need to dilate a tract, the insertion of a suprapubic tube, and the need for a urethral catheter[7]. There are other reported complications, including paralytic ileus, abdominal distention from the escape of irrigating fluid into the abdominal cavity, fever, and urine leakage[7]. Herein we evaluated the safety and efficacy of PCCL in managing bladder stones in male children less than 14 years.


  Patients and Methods Top


Between November 2016 and November 2017, 37 children had PCCL for their bladder and urethral stones. Any male child less than 14 years old age with single bladder or urethral stones was included in the study. Those with neurogenic bladder, augmented bladder, upper urinary tract stones requiring simultaneous ureteroscopy, percutaneous nephrolithotripsy or ureteral stent insertion, urethral stricture, stone in fossa navicularis that could be extracted after meatotomy, previous suprapubic procedures, multiple urethral/bladder calculi, severe skeletal malformation that prevents lithotomy position, and bleeding tendency were excluded. All patients were subjected to thorough history, clinical examination, and surgical fitness. Abdominal ultrasonography and kidney, ureter and bladder radiograph film were performed in all patients. Noncontrast computed tomography scan was performed in cases with radiolucent stones.

Under general anesthesia, sterilization was done, and parenteral third-generation cephalosporin was given to all patients. All patients had initial diagnostic urethrocystoscopy in lithotomy position using an operating compact 7-Fr cystourethroscope to evaluate stone burden and to exclude any anatomical abnormality. Urethral stones were pushed back to the bladder. A Foley's urethral catheter was fixed for continuous irrigation. Mild traction on urethral catheter was done for prevention of escape of stone fragments through the bladder neck. Then, the bladder was filled with 100–200 ml of normal saline. Access to the distended bladder was obtained by a 10 G needle in the midline, 1–2 cm above the pubic bone. Once suitable placement was confirmed with the return of bladder fluid, a guide wire was passed through the needle to the bladder. Dilatation was done using 8–10-Fr coaxial dilator. Then, a single fascial dilator 20 Fr in diameter with placement of a suitable sheath as a working tract was then introduced. No ultrasonic or fluoroscopic guidance was used to gain access to the bladder. Placement of a 12-Fr pediatric nephroscope through the sheath was done. Stone basket was used to extract the stone. If the stones were too large to be extracted through the used sheath, disintegration was performed with a pneumatic lithotripter or holmium: yttrium–aluminum–garnet laser. Stone retrieval then was done using stone basket. Primary skin closure of the suprapubic stab wound by a single 3–0 polyglycolic acid stitch was done. The urethral catheter was left for 48 h under coverage of antibiotics and analgesics. Later follow-up was done after 1 week by abdominal ultrasonography and plain kidney, ureter and bladder radiograph to confirm stone-free state and to exclude the presence of any complications. Success after procedure was defined as no residual stone fragments with no need to shift to other modality. Complications were graded according to the Uro-Clavien-Dindo classification system (2012).


  Results Top


In this study, the median age was 36 (12–144) months and median stone size was 11 (7–26) mm. Initial diagnosis was urethral stones in 26 (70.3%) patients and bladder stones in 11 (29.7%) patients. Noncontrast computed tomography scan was ordered in seven (18.9%) patients with radiolucent stones. The median operative time was 14 (5–45) min. Sixteen (43.2%) patients needed disintegration of their stones, of which 13 (81.25%) had pneumatic disintegration of their stones, whereas three (18.75%) had laser disintegration. Patients were followed up for periods ranged from 5 to 33 months (median 18 months).

Success was achieved in 36 (97.3%) patients. Failure of procedure was reported in only one case of a 66-month-old boy with a bladder stone 20 mm in diameter with trial of pneumatic disintegration. Development of intraperitoneal collection occurred that shifted the procedure to open cystolithotomy with retrieval of all stone fragments and drainage of collection.

Complications were reported in three (8.1%) cases, and prolonged catheterization was reported in two (5.4%) patients. One patient had subcutaneous fluid collection in the scrotum and suprapubic region owing to escape of irrigation fluid during percutaneous management of the stone. After scrotal skin release incision, the catheter was left for 1 week with antibiotic coverage over this period to guard against secondary infection until swelling subsided. One patient had prolonged catheterization because of failed percutaneous extraction of stone and intraperitoneal fluid collection owing to escape of irrigation fluid into the peritoneum that needed open cystolithotomy for stone delivery and drainage of free intraperitoneal collection. Another patient had his bladder stone entrapped in the subcutaneous tract that was managed by widening of skin incision and extraction of the stone.


  Discussion Top


Bladder stones represent 5% of all pediatric urolithiasis, reaching up to 15% in developing countries, with 1–5% incidence in developed world[8]. The need for an effective method for management of bladder stones in male children with sparing of the delicate, growing urethra led to the development of variant techniques aiming to extract bladder stones with the least morbidity.

Open suprapubic cystolithotomy was the procedure of choice for treating not only vesical calculi, but it also was the preferred method for managing posterior urethral stones after being pushed back to the bladder[6]. Being simple, cheap, achieving stone-free rate up to 100% in a single session, and sparing the urethra from manipulation had made open cystolithotomy the preferred method till now in some centers[6],[9]. A lot of modifications had been applied to the traditional open cystolithotomy aiming at decreasing hospital stay and morbidity[10]. Yet, this technique had the problem of prolonged catheterization, relative long hospital stay, suprapubic scar, and the risk of wound infection[6]. PCCL offers an alternative method for managing bladder calculi in children, with less operative time and morbidity compared with open cystolithotomy, with high success rates. Another advantage of PCCL is that it spares the delicate narrow-calipered urethra in children[11],[12]. It is the preferred method in treating stones in augmented bladder and in cases of bladder neck reconstruction[13].

[Table 1] shows the comparison between our case series and previous studies done by Ahmadnia et al.[12], Gan et al.[14], and Salah et al.[15] regarding managing bladder stones in children via PCCL.
Table 1: Comparison between our case series and other studies in managing bladder stones in children using percutaneous cystolithotomy technique

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In their case series, Gan et al.[14] and Salah et al.[15] fixed a suprapubic tube and a urethral catheter at the end of their PCCL procedures. Agrawal et al.[7] fixed a suprapubic tube only at the end of their case series of PCCL. In this study, we fixed a urethral catheter without a suprapubic tube to reduce patient morbidity and the need for further intervention and maneuver.

Safwat et al.[6] performed cystoscopic guided percutaneous suprapubic stone extraction for management of posterior urethral stones after being pushed back to the bladder using a hemostat without fluoroscopy. Another similar technique was described by Gamal et al.[16] for managing bladder and urethral stones. Both techniques are minimally invasive and effective in cases of small stones. This technique has limitation in cases of large or multiple stones. Moreover, there is no stable percutaneous tract with possibility of missing the access to the bladder during stone extraction and loss of the stone in the parietal layers.

Similar to Agrawal et al.[7] case series, we did not use fluoroscopic guidance to gain access to the bladder to minimize exposure to ionizing radiation in our series of pediatric patients. Depending on the anatomy of the bladder in children that it becomes an abdominal organ when it is full, we filled the bladder to its capacity by normal saline, and a puncture just 1–2 cm above pubic bone was done with a safe and satisfactory access to the bladder. Moreover, all patients had a urethral catheter for 48 h postoperatively (except two patients who had prolonged catheterization owing to complications).

Although transurethral cystolithotripsy has the advantage of short hospital stay and less morbidity compared with open cystolithotomy, concerns have aroused regarding the development of urethral stricture owing to prolonged operative time and multiple trials of stone fragment extraction[11]. The wide working tract in PCCL enabled us to extract stone easily with less operative time, and this favors PCCL in cases of large and multiple bladder stones. However, PCCL has the risk of bowel injury, paralytic ileus, and escape of irrigation fluid to the peritoneal cavity[7].

In Al-Marhoon et al.[11] case series of PCCL, complications were encountered in 3 patients in the form of intraperitoneal extravasation, which was managed by exploration. [Table 2] show complications encountered in our case series, the Uro-Clavien-Dindo classification of these complications and the method of management. In this study, we had an acceptable overall success rate in 36 (97.3%) cases compared with other studies. We had three (8.1%) patients with complications. One patient with escape of the stone in the subcutaneous tissue during PCCL who was managed without alternation of the procedure by widening of the skin and successful stone extraction, one patient with intraperitoneal fluid collection who was managed by exploration, and repair of the bladder tear with smooth postoperative period. The tubal drain was removed 2 days postoperatively and the catheter was removed 7 days after the procedure. One patient developed subcutaneous extravasation during PCCL and was managed by small multiple release incisions in the scrotum and prolonged catheterization for 7 days.
Table 2: Complications during case series, their Uro-Clavien-Dindo classification, and management

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  Conclusion Top


PCCL is a safe and effective method in treating with bladder stones in male children. Less cost and morbidity can be achieved by using a urethral catheter only to drain the bladder effectively postoperatively and minimizing the use of fluoroscopy to gain access to the bladder. Another study to compare PCCL with other modalities of managing bladder stones in children, especially transurethral route, is recommended.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

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Agrawal MS, Aron M, Goyal J, Elhence IP, Asopa HS. Percutaneous suprapubic cystolithotripsy for vesical calculi in children. J Endourol 1999; 13:173–175.  Back to cited text no. 7
    
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Rizvi SA, Naqvi SA, Hussain Z, Hashmi A, Hussain M, Zafar MN, et al. Pediatric urolithiasis: developing nation perspectives. J Urol 2002; 168:1522–1525.  Back to cited text no. 8
    
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Barnes RW, Bergman RT, Worton E. Litholapaxy vs. cystolithotomy. J Urol 1963; 89:680–681.  Back to cited text no. 9
    
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Rattan KN, Bhatia V, Ratan SK, Sharma M, Rohilla S. Catheterless and drainless open suprapubic cystolithotomy in children: a safe procedure. Pediatr Surg Int 2006; 22:255–258.  Back to cited text no. 10
    
11.
Al-Marhoon MS, Sarhan OM, Awad BA, Helmy T, Ghali A, Dawaba MS. Comparison of endourological and open cystolithotomy in the management of bladder stones in children. J Urol 2009; 181:2684–2687; [discussion 7–8].  Back to cited text no. 11
    
12.
Ahmadnia H, Younesi Rostami M, Yarmohammadi AA, Parizadeh SM, Esmaeili M, Movarekh M. Percutaneous treatment of bladder calculi in children: 5 years experience. Urol J 2006; 3:20–22.  Back to cited text no. 12
    
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Chaudhry R, Theisen KM, Stephany HA, Schneck FX, Cannon GM, Ost MC. Percutaneous Stone surgery in spina bifida patients – are stone-free rates worth the risk? J Endourol 2017; 31:S81–S86.  Back to cited text no. 13
    
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Gan W, Guo H, Yang R, Lian H, Yao L. Minimally invasive percutaneous cystolithotomy: an effective treatment for bladder stones in infants aged <1 year. BJU Int 2010; 106:275–277.  Back to cited text no. 14
    
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Salah MA, Holman E, Khan AM, Toth C. Percutaneous cystolithotomy for pediatric endemic bladder stone: experience with 155 cases from 2 developing countries. J Pediatr Surg 2005; 40:1628–1631.  Back to cited text no. 15
    
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